Modafinil could cause other Uncomfortable side effects. Call your health care provider For those who have any unusual troubles when having this medication.
modafinil will enhance the stage or result of diazepam intranasal by influencing hepatic enzyme CYP2C19 metabolism. Use Caution/Keep track of. Strong or moderate CYP2C19 inhibitors may possibly lessen fee of diazepam elimination, therefore growing adverse reactions to diazepam.
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phenytoin will decrease the level or outcome of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
modafinil will lessen the extent or effect of capivasertib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Strong or reasonable CYP3A inducers lessen capivasertib exposure, which may decrease efficacy.
Antonelli et al (1998) tested modafinil’s neuroprotective influence with regards to glutamate cytotoxicity by measuring GABA release and GABA uptake in cultured rat cortical neurons. They located that in contrast to glutamate receptor antagonists, modafinil was not able to absolutely stop Preliminary reductions in GABA launch, but modafinil was able to circumvent more information the additional reduction in GABA release above the following 50 percent hour which was witnessed while in the cells exposed to glutamate but not modafinil.
modafinil will lessen the extent or outcome of mavacamten by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
This medication might be prescribed for other makes use of; request your health practitioner or pharmacist To find out more.
larotrectinib will increase the level or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Not known.
They uncovered that modafinil promoted wakefulness by inhibiting the VLPO which was dependent on noradrenergic inhibition of VLPO neurons via an α2 adrenergic receptor.
Lin et al (1996) examined fos immunoreactivity in 26 Mind web sites of cats after the administration of amphetamine, methylphenidate, or modafinil. They located that modafinil induced very little fos-like immunoreactivity from the cortex, however it did induce fos labeling from the anterior hypothalamus and close by places, in distinction to amphetamine and methylphenidate.
ribociclib will enhance the degree or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
modafinil will decrease the level or result of pacritinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
posaconazole will enhance the amount or result of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.